Our design policy successfully achieves amortized intervention design on the distribution of the training environment while also generalizing well to distribution shifts in test-time design environments.

This paper presents a real time, data driven decision support framework for epidemic control. We combine a compartmental epidemic model with sequential Bayesian inference and reinforcement learning (RL) controllers that adaptively choose intervention levels to balance disease burden, such as intensive care unit (ICU) load, against socio economic costs. We construct a context specific cost function using empirical experiments and expert feedback. We study two RL policies: an ICU threshold rule computed via Monte Carlo grid search, and a policy based on a posterior averaged Q learning agent. We validate the framework by fitting the epidemic model to publicly available ICU occupancy data from the COVID 19 pandemic in England and then generating counterfactual roll out scenarios under each RL controller, which allows us to compare the RL policies to the historical government strategy. Over a 300 day period and for a range of cost parameters, both controllers substantially reduce ICU burden relative to the observed interventions, illustrating how Bayesian sequential learning combined with RL can support the design of epidemic control policies.

Innate resistance to anti-PD-1 immunotherapy remains a major clinical challenge in metastatic melanoma, with the underlying molecular networks being poorly understood. To address this, we constructed a dynamic Probabilistic Boolean Network model using transcriptomic data from patient tumor biopsies to elucidate the regulatory logic governing therapy response. We then employed a reinforcement learning agent to systematically discover optimal, multi-step therapeutic interventions and used explainable artificial intelligence to mechanistically interpret the agent's control policy. The analysis revealed that a precisely timed, 4-step temporary inhibition of the lysyl oxidase like 2 protein (LOXL2) was the most effective strategy. Our explainable analysis showed that this ''hit-and-run" intervention is sufficient to erase the molecular signature driving resistance, allowing the network to self-correct without requiring sustained intervention. This study presents a novel, time-dependent therapeutic hypothesis for overcoming immunotherapy resistance and provides a powerful computational framework for identifying non-obvious intervention protocols in complex biological systems.

Panic attacks are acute episodes of fear and distress, in which timely, appropriate intervention can significantly help individuals regain stability. However, suitable datasets for training such models remain scarce due to ethical and logistical issues. To address this, we introduce PACE, which is a dataset that includes high-distress episodes constructed from first-person narratives, and structured around the principles of Psychological First Aid (PFA). Using this data, we train PACER, a counseling model designed to provide both empathetic and directive support, which is optimized through supervised learning and simulated preference alignment. To assess its effectiveness, we propose PanicEval, a multi-dimensional framework covering general counseling quality and crisis-specific strategies. Experimental results show that PACER outperforms strong baselines in both counselor-side metrics and client affect improvement. Human evaluations further confirm its practical value, with PACER consistently preferred over general, CBT-based, and GPT-4-powered models in panic scenarios (Code is available at https://github.com/JihyunLee1/PanicToCalm ).

The COVID-19 pandemic underscored a critical need for intervention strategies that balance disease containment with socioeconomic stability. We approach this challenge by designing a framework for modeling and evaluating disease-spread prevention strategies. Our framework leverages multi-objective reinforcement learning (MORL) - a formulation necessitated by competing objectives - combined with a new stochastic differential equation (SDE) pandemic simulator, calibrated and validated against global COVID-19 data. Our simulator reproduces national-scale pandemic dynamics with orders of magnitude higher fidelity than other models commonly used in reinforcement learning (RL) approaches to pandemic intervention. Training a Pareto-Conditioned Network (PCN) agent on this simulator, we illustrate the direct policy trade-offs between epidemiological control and economic stability for COVID-19. Furthermore, we demonstrate the framework's generality by extending it to pathogens with different epidemiological profiles, such as polio and influenza, and show how these profiles lead the agent to discover fundamentally different intervention policies. To ground our work in contemporary policymaking challenges, we apply the model to measles outbreaks, quantifying how a modest 5% drop in vaccination coverage necessitates significantly more stringent and costly interventions to curb disease spread. This work provides a robust and adaptable framework to support transparent, evidence-based policymaking for mitigating public health crises.

Large language models have been widely used to simulate credible human social behaviors. However, it remains unclear whether these models can demonstrate stable capacities for stance formation and identity negotiation in complex interactions, as well as how they respond to human interventions. We propose a computational multi-agent society experiment framework that integrates generative agent-based modeling with virtual ethnographic methods to investigate how group stance differentiation and social boundary formation emerge in human-agent hybrid societies. Across three studies, we find that agents exhibit endogenous stances, independent of their preset identities, and display distinct tonal preferences and response patterns to different discourse strategies. Furthermore, through language interaction, agents actively dismantle existing identity-based power structures and reconstruct self-organized community boundaries based on these stances. Our findings suggest that preset identities do not rigidly determine the agents' social structures. For human researchers to effectively intervene in collective cognition, attention must be paid to the endogenous mechanisms and interactional dynamics within the agents' language networks. These insights provide a theoretical foundation for using generative AI in modeling group social dynamics and studying human-agent collaboration.

In this study, we investigate the use of large language models (LLMs), specifically ChatGPT, for structured deductive qualitative coding. While most current research emphasizes inductive coding applications, we address the underexplored potential of LLMs to perform deductive classification tasks aligned with established human-coded schemes. Using the Comparative Agendas Project (CAP) Master Codebook, we classified U.S. Supreme Court case summaries into 21 major policy domains. We tested four intervention methods: zero-shot, few-shot, definition-based, and a novel Step-by-Step Task Decomposition strategy, across repeated samples. Performance was evaluated using standard classification metrics (accuracy, F1-score, Cohen's kappa, Krippendorff's alpha), and construct validity was assessed using chi-squared tests and Cramer's V. Chi-squared and effect size analyses confirmed that intervention strategies significantly influenced classification behavior, with Cramer's V values ranging from 0.359 to 0.613, indicating moderate to strong shifts in classification patterns. The Step-by-Step Task Decomposition strategy achieved the strongest reliability (accuracy = 0.775, kappa = 0.744, alpha = 0.746), achieving thresholds for substantial agreement. Despite the semantic ambiguity within case summaries, ChatGPT displayed stable agreement across samples, including high F1 scores in low-support subclasses. These findings demonstrate that with targeted, custom-tailored interventions, LLMs can achieve reliability levels suitable for integration into rigorous qualitative coding workflows.